Wednesday, 9 October 2013

MTRAC review perampanel and zonisamide

The latest MTRAC committee meeting discussed the prescribing of perampanel adjunctive therapy and zonisamide monotherapy for the treatment of partial (or focal) seizures in epilepsy.

It was the committee’s opinion that perampanel should only be used in a tertiary care setting, and that patients receiving treatment with perampanel were likely to receive continued specialist supervision and treatment.

With zonisamide the committee agreed that zonisamide monotherapy should only be considered when other NICE-recommended first- and second-line treatment options have proved ineffective or are not tolerated.

Each of the commissioning support sheets can be accessed from

The next committee meeting is on the 24th October and will be discussing nalmefene for the treatment of alcohol dependency and melatonin for the treatment of primary insomnia.

If you’d like to know more about MTRAC or join the mailing list, more information is available from our website at


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